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Cefpirome is another broad spectrum cephalosporin for intravenous use. Its antimicrobial activity is similar to that of cefotaxime.
The reconstituted drug can be injected over 3-5 minutes or given as a 20-30 minute infusion. Clearance is mainly renal so a lower dose is given if creatinine clearance is reduced. The half life is 2 hours, but cefpirome can usually be given twice a day.