Urea - Berthelot is the end product of protein metabolism. It is synthesized in the liver and transported to the kidney for excretion. Increased Urea / Urea Nitrogen levels are associated with renal diseases as well as dehydration, gastrointestinal hemorrhage, and diabetic coma. Decreased values are observed in some cases of severe liver diseases. Urea can be estimated in serum/plasma using Urease / Chromogen method.